Wednesday 10 October 2018 12:31 am Almost two thirds of women look at a prospective employer’s gender pay gap before applying to a job, a new study has found. Women put off by gender pay gaps when looking for new jobs, study finds “They want action, and if they don’t see change there is a very real risk that they won’t join you or, most importantly, stay with you. It will also affect their commitment to you.“It’s crucial that all employers think seriously about this issue and demonstrate to their workforce that they are committed to closing the gender pay gap.“A working environment which allows everyone to achieve their full potential is vital. If you don’t deliver on this you will fail to access a huge talent pool and will put your business at real competitive disadvantage.”All those surveyed came from companies with 250 or more employees, which are required to publish data on their gender pay gaps. August Graham Tags: Trading Archive whatsapp Share whatsapp Women also said their motivation is reduced when employed at a company with a pay gap, and they are less likely to recommend working there to a friend.A poll by the Equality and Human Rights Commission of over 2,500 employees found that young women and minorities were especially demotivated by inequality.Among men, 39 per cent said they would feel less proud to work for an employer with a gender pay gap. Nearly two thirds of women said the same.A majority of both men and women said they would like to help their employers tackle pay inequality, however a quarter think they have no influence.Equality and Human Rights Commission chair David Isaac, is today expected to say: “The message to all employers from your existing and prospective female staff is very clear from these results.
whatsapp “There is much more that we would like to say but, given ongoing proceedings in respect of other matters and the possibility that the Azeri government may appeal, we will not be making any further comment at this stage. Whilst we understand the interest in this case we ask that the press please respect her family’s right to privacy.” Share Read more: The UK’s newest weapon in the war against dirty money Read more: Mystery woman who spent £16m in Harrods revealed as wife of jailed Azerbaijan banker A judge ruled today that a woman who spent £16m in Harrods and was the target of the UK’s first unexplained wealth order (UWO) will not be extradited to Azerbaijan. Thursday 26 September 2019 7:58 pm whatsapp James Booth Read This Next20 Stars Who’ve Posted Nude Selfies, From Lizzo to John Legend (Photos)The WrapIf You’re Losing Hair in This Specific Spot, It Might Be a Thyroid IssueVegamourLimited Series About Vincent Chin Murder in the Works at ParticipantThe WrapRicky Schroder Calls Foo Fighters’ Dave Grohl ‘Ignorant Punk’ forThe WrapBest Wine Gifts & Wine Accessories at Every PriceGayot50,000-Plus People Want Jeff Bezos to Go to Space and Never Come BackThe WrapTop 5 Tips If You’re Losing Your EyebrowsVegamourWhat Causes Hair Loss? Every Trigger ExplainedVegamourSmoking and Hair Loss: Are They Connected?Vegamour Hajiyeva’s lawyer, Roger Gherson of Gherson Solicitors, said: “We welcome the decision of the Senior District Judge today, which confirms that our client, Mrs Hajieva, will not be extradited to Azerbaijan. Zamira Hajiyeva, whose banker husband is serving a 15-year sentence for fraud and embezzlement, faced extradition to Azerbaijan to stand trial on multiple fraud charges. Woman who spent £16m in Harrods will not be extradited to Azerbaijan Hajiyeva was the target of the UK’s first UWO which forced her to reveal how she was able to afford two UK properties worth a combined £22m. Senior District Judge Emma Arbuthnot said in her judgment that “there is a real risk that Mrs Hajiyeva whose case is high-profile and sensitive and not a ‘normal’ criminal case will suffer a flagrant denial of justice.” However, a district judge ruled today she would not receive a fair trial in the former Soviet republic.
Banks worldwide have been taking measures to offset risk amid the crisis. Also Read: Santander first quarter profit plunges 82 per cent on coronavirus Excluding extraordinary provisions, which included €46m of restructuring costs in Europe, Santander’s underlying quarterly profit rose one per cent to €1.98bn. whatsapp US lenders have set aside billions of dollars to cover potential loan defaults, while European players such as Credit Suisse and Deutsche Bank have been doing likewise. Santander too has boosted its lending capacity partly by scrapping its final 2019 dividend, after a regulatory directive to do so to support an economy hamstrung by curbs. Overall loan-loss provisions rose 80 per cent after the bank set aside €1.6bn to offset the impact from Covid-19 based on the expected deterioration of the macroeconomic conditions arising from the health crisis. Spain’s Santander bank posted an 82 per cent year-on-year slump in quarterly net profit todayas it booked higher provisions for expected credit losses from the coronavirus outbreak. Also Read: Santander first quarter profit plunges 82 per cent on coronavirus Show Comments ▼ “We will review our strategic targets once we have a more complete understanding of the full impact of the crisis,” Santander chairman Ana Botin said in a statement. whatsapp The respiratory disease caused by the new coronavirus has so far killed 23,521 people in Spain. by Taboolaby TaboolaSponsored LinksSponsored LinksPromoted LinksPromoted LinksYou May LikeDaily FunnyFemale Athlete Fails You Can’t Look Away FromDaily Funnyzenherald.comMeghan Markle Changed This Major Detail On Archies Birth Certificatezenherald.comBleacherBreaker4 Sisters Take The Same Picture For 40 Years. Don’t Cry When You See The Last One!BleacherBreakerMisterStoryWoman files for divorce after seeing this photoMisterStorybonvoyaged.comThese Celebs Are Complete Jerks In Real Life.bonvoyaged.comNoteableyJulia Robert’s Daughter Turns 16 And Looks Just Like Her MomNoteableyNational Penny For Seniors7 Discounts Seniors Only Get If They AskNational Penny For SeniorsJustPerfact USAMan Decides to File for Divorce After Taking a Closer Look at This Photo! JustPerfact USABetterBe20 Stunning Female AthletesBetterBe Including the full implementation of new accounting standard IFRS-9, with an impact of 25 basis points, Santander’s capital ratio stood at 11.33 per cent. Reuters As of end-March, Santander had a core tier-1 capital ratio – the strictest measures of solvency – of 11.58 per cent compared to 11.65 per cent at end-December. The Eurozone’s second-largest bank by market value reported a profit of €331m (£288.5m) for the first quarter ended in March. Share Tuesday 28 April 2020 7:31 am That was slightly better than an average analyst estimate of €1.8bn drawn from a Reuters poll. More From Our Partners Astounding Fossil Discovery in California After Man Looks Closelygoodnewsnetwork.orgRussell Wilson, AOC among many voicing support for Naomi Osakacbsnews.comFeds seized 18 devices from Rudy Giuliani and his employees in April raidnypost.comPolice Capture Elusive Tiger Poacher After 20 Years of Pursuing the Huntergoodnewsnetwork.orgBiden received funds from top Russia lobbyist before Nord Stream 2 giveawaynypost.comBrave 7-Year-old Boy Swims an Hour to Rescue His Dad and Little Sistergoodnewsnetwork.orgUK teen died on school trip after teachers allegedly refused her pleasnypost.comA ProPublica investigation has caused outrage in the U.S. this weekvaluewalk.comNative American Tribe Gets Back Sacred Island Taken 160 Years Agogoodnewsnetwork.orgKiller drone ‘hunted down a human target’ without being told tonypost.com‘Neighbor from hell’ faces new charges after scaring off home buyersnypost.comMatt Gaetz swindled by ‘malicious actors’ in $155K boat sale boondogglenypost.comWhy people are finding dryer sheets in their mailboxesnypost.comInside Ashton Kutcher and Mila Kunis’ not-so-average farmhouse estatenypost.com980-foot skyscraper sways in China, prompting panic and evacuationsnypost.comFlorida woman allegedly crashes children’s birthday party, rapes teennypost.comKamala Harris keeps list of reporters who don’t ‘understand’ her: reportnypost.comConnecticut man dies after crashing Harley into live bearnypost.com Tags: Coronavirus Santander Santander first quarter profit plunges 82 per cent on coronavirus
The US has vowed to slap tariffs of up to 100 per cent on $2.4bn (£1.6bn) of French goods, in retaliation over findings that a new digital services tax in the country would harm US tech companies. France to push ahead with tax on internet giants despite US anger France will push ahead with its tax on internet giants this year, its finance minister said today. However, the fallout from the coronavirus outbreak has left finance ministries more focused on saving their economies than overhauling outdated tax rules, making a deadline of the end of the year to wrap up the talks look increasingly compromised. Nearly 140 countries are negotiating the first major rewriting of international tax rules in more than a generation, to take better account of the rise of big tech companies that often book profit in low-tax countries. In January France offered to suspend its tax on big digital companies’ income in until the end of the year while an international agreement on cross-border taxation was negotiated this year. James Booth Also Read: France to push ahead with tax on internet giants despite US anger whatsapp Also Read: France to push ahead with tax on internet giants despite US anger In December the US threatened to hit French exports to the US with steep tariffs in retaliation for the new tax. Share Thursday 14 May 2020 5:45 pm Also Read: France to push ahead with tax on internet giants despite US anger France’s national tax has been a source of contention with Washington, which considers that it unfairly targets US digital companies. US trade representative Robert Lighthizer said its investigation found that the French proposal was “inconsistent with prevailing principles of international tax policy, and is unusually burdensome for affected US companies”, such as Google , Facebook, Apple and Amazon. Ad Unmute by Taboolaby TaboolaSponsored LinksSponsored LinksPromoted LinksPromoted LinksYou May LikeBleacherBreaker4 Sisters Take The Same Picture For 40 Years. Don’t Cry When You See The Last One!BleacherBreakerUndoMisterStoryWoman Files For Divorce After Seeing This Photo – Can You See Why?MisterStoryUndobonvoyaged.comTotal Jerks: These Stars Are Horrible People.bonvoyaged.comUndoDaily FunnyFemale Athlete Fails You Can’t Look Away FromDaily FunnyUndoNational Penny For Seniors7 Discounts Seniors Only Get If They AskNational Penny For SeniorsUndozenherald.comMeghan Markle Changed This Major Detail On Archies Birth Certificatezenherald.comUndoPost FunThe Deadliest Snakes Ever Found On The PlanetPost FunUndoGloriousaOctomom’s Kids Are All Grown Up. Here’s How They Turned OutGloriousaUndoBeach RaiderMom Belly Keeps Growing, Doctor Sees Scan And Calls CopsBeach RaiderUndo “Never has a digital tax been more legitimate and more necessary,” Finance Minister Bruno Le Maire told journalists, adding that big digital companies were doing better than most during the coronavirus crisis. whatsapp “In any case, France will apply as it has always indicated a tax on digital giants in 2020 either in an international form if there is a deal or in a national form if there is no deal,” Le Maire said. Show Comments ▼
And yet, still many of them are still stuck onboard due to the lockdown and unable to be with their loved ones. They’ve kept our shelves stocked, now it’s time to stand up for our seafarers Maritime is quite simply the facilitator of free trade and our market economy, the tool that powers the engine of prosperity. Thousands of lives have been lost and the global economy has been set back by many years. whatsapp Without seafarers and their skills we would be in a vastly different situation to where we are now, facing shortages of essential goods (Getty Images) Also Read: They’ve kept our shelves stocked, now it’s time to stand up for our seafarers Show Comments ▼ Nusrat GhaniNusrat Ghani is Conservative MP for Wealden But there is another pandemic taking place behind the scenes — a hidden pandemic that may cause myriad unintended but disastrous consequences. And that is the plight of our seafarers around the world. Even in a landlocked constituency such as my own of Wealden, one local resident wrote in and told me that ships are now sailing the seas in “unseaworthy” conditions due to the “extreme mental and physical stress” of seafarers. He fears that these grave health and safety concerns are only going to become worse. The situation is already dire. At Tilbury docks, 47 mainly Indian seafarers from the passenger vessel Astoria are on hunger strike, after weeks of pleas to their employer for back pay and repatriation produced no results. Tragically, a number of suicides have been reported around the world, and suicide attempts onboard ships stranded offshore or in port are now the foremost cause of deaths among seafarers. This week is Seafarers Awareness week, and it is important we mark this moment, as without seafarers and their skills we would be in a vastly different situation to where we are now — facing empty supermarket shelves and shortages of essential goods. City A.M.’s opinion pages are a place for thought-provoking views and debate. These views are not necessarily shared by City A.M. Nor is seafaring just about the ships themselves. There is an entire industry of professional services around maritime trade. whatsapp by Taboolaby TaboolaSponsored LinksSponsored LinksPromoted LinksPromoted LinksYou May LikeNoteableyJulia Robert’s Daughter Turns 16 And Looks Just Like Her MomNoteableyDaily FunnyFemale Athlete Fails You Can’t Look Away FromDaily Funnybonvoyaged.comThese Celebs Are Complete Jerks In Real Life.bonvoyaged.comJustPerfact USAMan Decides to File for Divorce After Taking a Closer Look at This Photo! JustPerfact USAFinanceChatterViewers Had To Look Away When This Happened On Live TVFinanceChatterPost Fun25 Worst Movies Ever, According To Rotten TomatoesPost FunZen HeraldEllen Got A Little Too Personal With Blake Shelton, So He Said ThisZen HeraldMisterStoryWoman Files For Divorce After Seeing This Photo – Can You See Why?MisterStoryBleacherBreaker4 Sisters Take The Same Picture For 40 Years. Don’t Cry When You See The Last One!BleacherBreaker The International Maritime Organisation (IMO) and the International Chamber of Shipping have done a tremendous job putting forward a 12-step plan for countries to implement safe crew changes. But it has become increasingly apparent over recent weeks that there is a tragic lack of leadership and coordination on a global scale. Since March, many countries have refused to allow crew changes at ports or shore leave, forcing mariner contracts to be extended. Some seafarers have been on board their vessels for over 15 months. And while some are being paid for this extra time, they are doing their jobs without the breaks they’re entitled to, often working 12 hours a day, seven days a week, putting their physical and mental health at risk. Main image credit: Getty These men and women don’t go home every night to help with the homework and put the kids to bed — they’re busy delivering all of the goods that we depend on for our survival, most notably our food, medicines and fuel. The “out of sight, out of mind” attitude that most world leaders seem to have adopted will become slightly more difficult to maintain when our supply chains that bring food and medicine to our supermarket shelves begin to shut down. These are key workers. They are what keeps freight travelling around the world, and some of them haven’t had a day’s break in months. We can only begin to imagine the horror of their plight, or how it must feel when many governments around the world simply turn a blind eye to their despair and exhaustion. Without seafarers and their skills we would be in a vastly different situation to where we are now, facing shortages of essential goods (Getty Images) About 80 per cent of world goods are carried by ships. For Britain, around 95 per cent of our imports and exports in goods are moved by sea, including 25 per cent of the UK’s energy supply and 48 per cent of the country’s food supplies. The UK is the world’s leading maritime nation and we are also home to the IMO, which gives us a unique responsibility in leading on this crisis. Last week, I asked the Prime Minister in the House of Commons if he would agree to meet with the Chambers of Shipping to marshal the global community to help get our seafarers home and ensure that free trade continues to flow. Thankfully, he agreed to do just that. The City of London is a global leader in this area, with its unparalleled expertise in law, arbitration, shipbroking, financial services and consultancy. Indeed, the largest share of worldwide marine insurance premiums and shipbroking transactions occur in the UK, comprising 35 per cent and 26 per cent of the global market respectively, and these maritime services are embedded within the City’s wider financial sector, where London also continues to be a premier hub. Thursday 9 July 2020 9:50 am Without seafarers and their skills we would be in a vastly different situation to where we are now, facing shortages of essential goods (Getty Images) Also Read: They’ve kept our shelves stocked, now it’s time to stand up for our seafarers The Covid-19 pandemic has been a desperately worrying time for many people all over the country, in virtually every sector. Share Yet over 200,000 seafarers are currently stuck at sea, due to the failure of the global diplomatic community to make an agreement on crew changes in light of the travel restrictions imposed as a result of Covid-19. More From Our Partners Biden received funds from top Russia lobbyist before Nord Stream 2 giveawaynypost.comPolice Capture Elusive Tiger Poacher After 20 Years of Pursuing the Huntergoodnewsnetwork.orgInside Ashton Kutcher and Mila Kunis’ not-so-average farmhouse estatenypost.comRussell Wilson, AOC among many voicing support for Naomi Osakacbsnews.comA ProPublica investigation has caused outrage in the U.S. this weekvaluewalk.comBrave 7-Year-old Boy Swims an Hour to Rescue His Dad and Little Sistergoodnewsnetwork.orgFlorida woman allegedly crashes children’s birthday party, rapes teennypost.comNative American Tribe Gets Back Sacred Island Taken 160 Years Agogoodnewsnetwork.orgAstounding Fossil Discovery in California After Man Looks Closelygoodnewsnetwork.org Opinion Progress can be made. Britain should grasp this opportunity to stand up for seafarers and save global supply chains from crashing to a disastrous halt.
whatsapp Share Tags: NULL Best of the Brokers for 12 December 2014 Express KCS To appear in Best of the Brokers, email your research to [email protected] MEDIAWesthouse Securities has moderated its rating from “buy” to “add”, to reflect that the upside to its 71p target price has been reduced by recent share price strength. The broker said this performance was well deserved due to the positive initiatives implemented since the arrival of chief executive Adria Vidler.HANGAR 8Cantor Fitzgerald has reiterated its “buy” rating. The firm recently announced the proposed acquisition of Gama Aviation Holdings, and Cantor said the transaction would mean that profits could double over the next three years with more aircraft under management and increased cross-selling of service.HISCOXCanaccord Genuity reiterated its “hold” rating. The broker reported that Hiscox was planning to keep its catastrophe appetite unchanged going into 2015, and said it expected a good end to the year for the firm, given the low level of catastrophes and large losses year-to-date. whatsapp Show Comments ▼ Read This Next’A Quiet Place Part II’ Sets Pandemic Record in Debut WeekendFamily ProofHiking Gadgets: Amazon Deals Perfect For Your Next AdventureFamily ProofAmazon roars for MGM’s lion, paying $8.45 billion for studio behind JamesFamily ProofIndian Spiced Vegetable Nuggets: Recipes Worth CookingFamily ProofCheese Crostini: Delicious Recipes Worth CookingFamily ProofHomemade Tomato Soup: Delicious Recipes Worth CookingFamily ProofWhat to Know About ‘Loki’ Ahead of Disney+ Premier on June 9Family ProofChicken Bao: Delicious Recipes Worth CookingFamily ProofBaked Sesame Salmon: Recipes Worth CookingFamily Proof Thursday 11 December 2014 8:35 pm
General Election 2015: Poll Tax popularity resurges among Tory and Ukip supporters – but only if you don’t call it by its name
Tuesday 31 March 2015 7:54 am Tags: General Election 2015 General Election 2015: Poll Tax popularity resurges among Tory and Ukip supporters – but only if you don’t call it by its name Share Show Comments ▼ by Taboolaby TaboolaSponsored LinksSponsored LinksPromoted LinksPromoted LinksYou May LikeMoneyPailShe Was A Star, Now She Works In ScottsdaleMoneyPailzenherald.comMeghan Markle Changed This Major Detail On Archies Birth Certificatezenherald.comMaternity WeekA Letter From The Devil Written By A Possessed Nun In 1676 Has Been TranslatedMaternity WeekComedyAbandoned Submarines Floating Around the WorldComedyEquity MirrorThey Drained Niagara Falls — They Weren’t Prepared For This Sickening DiscoveryEquity MirrorNoteableyKirstie Alley Is So Skinny Now And Looks Like A BarbieNoteableyOpulent ExpressHer Quadruplets Were Born Without A Hitch. Then Doctors Realized SomethingOpulent ExpressMoneyWise.com15 States Where Americans Don’t Want To Live AnymoreMoneyWise.comBridesBlushThis Is Why The Royal Family Kept Quiet About Prince Harry’s Sister BridesBlush It was arguably the least popular tax ever levied in the UK, and contributed to the demise of the Iron Lady, but nearly 25 years after the Poll Tax was first introduced it seems some voters would approve its return.Back in 1990 around 200,000 people took to the streets to protest the introduction of the Community Charge, which would apply a flat rate of tax to each individual rather than their property, leading to the worst riots in 100 years. And yet a poll carried out by YouGov to mark the anniversary of the riots suggests that 44 per cent of those who voted Tory in the 2010 election would support bringing it back – without using the “Poll Tax” tag – while 39 per cent said they would oppose it. One in four Ukip supporters said they approved. On average, 31 per cent of respondents said they would support its return, compared with 46 per cent who said they would oppose it. Liberal Democrats were the least keen, with 21 per cent supporting it versus 68 per cent opposing. Tories were least likely to strongly oppose the tax – with just 17 per cent recording that as their response, compared with 30 per cent for Labour supporters and 39 per cent for Liberal Democrats. When the pollsters introduced the phrase Poll Tax, those numbers shifted, although 39 per cent of Tory voters said it was a good policy, with 29 per cent saying it was bad. The numbers shift when you introduce the phrase “Poll Tax” (Source: YouTube) Some 14 per cent of Labour and Lib Dem supporters said it was good, compared with 60 per cent and 57 per cent who said respectively it was a bad policy. When it comes to whether it was right for people to refuse to pay it, Ukip supporters shift their views, with 47 per cent agreeing it was an “unfair tax” that people were right to resist. Only Labour had a higher level of support on this point, at 48 per cent. More than two-thirds of Conservatives (68 per cent) and half of Liberal Democrats (51 per cent) said it was unacceptable for people to refuse to pay tax. Ukip supporters were also most vocal when it came to the current system, with 67 per cent saying it was unfair, compared with the average of 44 per cent. whatsapp whatsapp More From Our Partners Brave 7-Year-old Boy Swims an Hour to Rescue His Dad and Little Sistergoodnewsnetwork.orgBiden received funds from top Russia lobbyist before Nord Stream 2 giveawaynypost.comRussell Wilson, AOC among many voicing support for Naomi Osakacbsnews.comUK teen died on school trip after teachers allegedly refused her pleasnypost.comNative American Tribe Gets Back Sacred Island Taken 160 Years Agogoodnewsnetwork.org‘Neighbor from hell’ faces new charges after scaring off home buyersnypost.comAstounding Fossil Discovery in California After Man Looks Closelygoodnewsnetwork.orgA ProPublica investigation has caused outrage in the U.S. this weekvaluewalk.comPolice Capture Elusive Tiger Poacher After 20 Years of Pursuing the Huntergoodnewsnetwork.orgMatt Gaetz swindled by ‘malicious actors’ in $155K boat sale boondogglenypost.comKamala Harris keeps list of reporters who don’t ‘understand’ her: reportnypost.com980-foot skyscraper sways in China, prompting panic and evacuationsnypost.comFlorida woman allegedly crashes children’s birthday party, rapes teennypost.comKiller drone ‘hunted down a human target’ without being told tonypost.comWhy people are finding dryer sheets in their mailboxesnypost.comI blew off Adam Sandler 22 years ago — and it’s my biggest regretnypost.comInside Ashton Kutcher and Mila Kunis’ not-so-average farmhouse estatenypost.comSupermodel Anne Vyalitsyna claims income drop, pushes for child supportnypost.com Catherine Neilan
BusinessThis biotech company is trying to make a rare disease drug cheaper. Will it work? Related: Allison Moore, who has Charcot-Marie-Tooth, or CMT, is the founder of the Hereditary Neurotherapy Foundation. Pharnext, a French drug maker, is developing a treatment for the disorder. Chantal Heijnen for STAT If Pharnext succeeds in its plans, it will charge $20,000 to $60,000 for annual treatments — a hefty sum, but considerably less than the kinds of drug prices that have triggered allegations of price-gouging among patients and consumer advocates. It could also show other drug makers that it’s possible to drastically reduce research-and-development costs to produce breakthrough treatments, which in turn would allow them to charge less.Pharnext has “been a game-changer,” said Allison Moore, who has Charcot-Marie-Tooth, or CMT, and is the founder of the Hereditary Neurotherapy Foundation.advertisement “We are a little bit romantic, but not that much.” How a system meant to develop drugs for rare diseases broke down Related: By Dylan Scott Jan. 20, 2016 Reprints “I do think that they will deliver on the pricing,” she said. “If the pricing can be low, that can also be a trend for these other rare diseases.” It remains to be seen whether that’s the case. But experts who track drug pricing said that the company’s reported strategy seems unusual.“First, they revealed what their pricing would be for a drug that hasn’t been approved. … Companies tend not to reveal anything about pricing before approval,” said Joshua Cohen, an associate professor at the Tufts Center for the Study of Drug Development. “Second, they are not going with a price that would maximize their profits. This is not unheard of, but not common. As with any commodity-selling company, drug firms usually price their products in such a way as to maximize profits.”Dr. Brian O’Sullivan of the Children’s Hospital at Dartmouth, who has written about drug prices, called Pharnext’s stated approach “refreshing.”“I think that there’s been a lot of concern in the general public about people looking to make the biggest possible profit,” he said. “You don’t have to make billions when you could make hundreds of billions.” Dr. Daniel Cohen, chief executive of Pharnext An estimated 2.8 million people worldwide have been diagnosed with a disease known as Charcot-Marie-Tooth disorder, an inherited muscular atrophy condition. The disease causes debilitating muscle weakness that can sometimes require leg braces.There is no existing drug to treat it.Pharnext, a French drug maker developing a treatment, hopes to change that. But what may set the firm apart is less its work on an experimental drug than its stated determination to do something else: keep the drug affordably priced.advertisement STAT-Harvard poll: Dismayed by drug prices, public supports Democrats’ ideas The question is if the company can make the economics work. The drug industry and its defenders have repeatedly said that high prices are justified by the high cost of developing new drugs. Research is expensive, and much of it fails. Even former Turing Pharmaceuticals CEO Martin Shkreli, who has received so much public scorn, rationalized a 5,000 percent price increase in part by saying that his company planned to invest in research for treating rare diseases.That might be argument that much of the public does not accept — about 53 percent of Americans say the drive for company profits is driving the cost of prescription drugs. But there’s no disputing that research and development requires significant investment.Some drug companies will spend upwards of $1 billion to develop drugs for rare diseases, and then price the treatment at $100,000 or more per year.Left: Pharnext has mapped Alzheimer’s disease in the brain to help combine existing drugs with the company’s experimental agent; Right: Pharnext’s facilities in Paris, France. Courtesy PharnextDr. Daniel Cohen, the chief executive of Pharnext, who launched his career by helping map the human genome, said it doesn’t have to be that way.“Do we want to charge less to save the system, or do we want to make short-term money?” Cohen said in an interview with STAT. He and his colleagues came down somewhere in the middle.“We are a little bit romantic, but not that much,” he said.Pharnext has developed a process known as pleotherapy, which it said could hold promise for the future of drug-making. It involves combining existing drugs and repurposing them to treat new conditions and lowering the doses involved to ward off side effects. The firm’s treatment for the main strain of CMT will probably cost $40 to $50 million to develop if all goes well, Cohen said. By keeping research costs in check, Pharnext says it will be able to charge consumers less. Pharnext hasn’t yet gotten its first product to market yet, however — and likely won’t until 2019, assuming the CMT treatment is approved.Still, Cohen is seen by some as a mirror image of Shkreli, who was unapologetic about hiking prices, saying his decision was justified by his desire to pursue cures for rare diseases and his responsibility to shareholders.Cohen said he didn’t want to be critical of Shkreli. But he also said that the current research-and-development model is too expensive because it fails too often and that financial interests tend to exacerbate the problem.“If there is exaggeration from companies — to over, over, overprice despite a small cost — I would say this might exist,” Cohen said. “But frankly, the guilty is not the company. The guilty is Wall Street because they put pressure on people.”Pharnext’s medical philosophy is a bit unorthodox in the age of personalized medicine, especially given Cohen’s role at its origins in documenting the human genome. The bottom line, he said, is that highly individualized treatment is often too expensive to produce and that leads to higher prices. Combining older drugs, on the other hand, could be cheaper and a cocktail that treats Alzheimer’s disease might also help treat Parkinson’s, broadening the patient pool and in turn helping lower prices.Allison Moore, who has CMT, displays the braces she must wear on her legs. The disease causes debilitating muscle weakness that can sometimes require leg braces. Chantal Heijnen for STATNot everyone is sold on his approach. Several experts pointed out that the actual ingredients being used by Pharnext — the older drugs that make up his cocktail — are available at a very cheap price.“It’s wonderful to develop a therapy for rare conditions, which, if truly effective in improving quality of life for patients, should be rewarded,” said Dr. Walid Gellad, a professor who studies drug prescribing at the University of Pittsburgh, adding that he had not examined Pharnext’s plans extensively. “But I’m not sure I see altruism here as opposed to limits on what people will pay for these older drugs in combination.”Even those who praised Cohen’s pricing philosophy acknowledged that he isn’t investing the same kind of money into basic research that other companies are.“It’s a little easier for them to say they’re going to price it lower because they’re not putting as much in on the front end,” O’Sullivan said, though he added that “some other companies have used that as an excuse to overcharge.”Regardless of altruism or lack thereof, Cohen will have an important ally: patient advocates. After Turing Pharmaceuticals hiked the price of an older anti-parasitic drug by more than 5,000 percent last year, AIDS groups whose constituencies relied on the drug were outraged.Pharnext, on the other hand, has the enthusiastic backing of Moore’s group, the Hereditary Neurotherapy Foundation. Moore met personally with Cohen and his colleagues in Paris in 2013 and helped set up the US trials for their drug.“I really feel it’s not just about making money,” Moore said of Pharnext and Cohen. “He really wants to make a difference.”Correction: An earlier version of this story misstated the hospital where Dr. Brian O’Sullivan works. Tags drug developmentdrug pricesrare diseases
Home News Increase in cases moves Laois to 12th highest incidence rate of Covid-19… News WhatsApp Pinterest Electric Picnic organisers release statement following confirmation of new festival date Pinterest RELATED ARTICLESMORE FROM AUTHOR Increase in cases moves Laois to 12th highest incidence rate of Covid-19 in Ireland Twitter Now, just Donegal, Monaghan, Dublin, Roscommon, Clare, Longford, Cavan, Cork, Limerick, Offaly and Kildare have a higher 14-day rate of infection that Laois.The decision to move the entire country to Level 3 restrictions is vindicated when you compare what happened to Laois, Offaly and Kildare back in August.It lasted in Laois for two weeks and meant hotels and restaurants were forced to close while so too were pubs (that were selling food) and people were instructed not to leave the county or come into it.The metric, we were told, for determining this at the time was the incidence rate of the virus in the three counties.Kildare had 82.25, Offaly had 80.81 and Laois had 69.66. Right now, 19 counties have an incidence rate greater than 69.66 that Laois had back then.In the last seven days alone, there have been 60 new cases confirmed in Laois.In the previous 14 up to September 28, the figure was 27.14-day incidence rate up to Tuesday October 6 Donegal – 312.2 (211.1)Monaghan – 257.4 (133.6)Dublin – 171.4 (159.3)Roscommon – 170.4 (102.3)Clare – 157.4 (60.6)Longford – 154.1 (73.4)Cavan – 144.4 (56.4)Cork – 118.8 (81.2)Limerick – 107.7 (41)Offaly – 105.2 (65.4)Kildare 95.7 (84.9)Laois – 95.6 (34.2)Louth – 84.6 (76.8)Galway – 96.9 (73.2)Meath – 96.9 (53.3)Sligo – 90 (29)Westmeath – 89 (50.7)Wicklow – 77.2 (72.3)Wexford – 72.1 (32.7)Kerry – 64.3 (19.6)Tipperary – 54.5 (24.4)Kilkenny – 51.4 (26.2)Carlow – 42.2 (28.1)Mayo – 39.1 (26.8)Leitrim – 34.3 (12.5)Waterford- 31.8 (52.5)SEE ALSO – WATCH: Laois woman’s encounter with Freddie the fox makes ITV News By Alan Hartnett – 8th October 2020 Electric Picnic Laois Councillor ‘amazed’ at Electric Picnic decision to apply for later date for 2021 festival WhatsApp News Laois has the 12th highest 14-day incidence rate of Covid-19 in Ireland.The latest figures from the Department of Health shows the O’Moore County has an average 95.6 cases per 100,000.These are figures from midnight on Tuesday October 6 and show that Laois has dramatically increased from 34.2 cases per 100,000 where they were on the same day last week. The comparison between this week and last shows that every single county in the country – bar one – has shown an increase in incidence rate.Only Waterford has shown an improvement with Laois moving from 18th position to 12th. Bizarre situation as Ben Brennan breaks up Fianna Fáil-Fine Gael arrangement to take Graiguecullen-Portarlington vice-chair role Electric Picnic TAGSCoronavirusCovid-19 Facebook Facebook Twitter Previous article13th winner of the season for Laois trainer following Navan successNext articleFunding for library supports as new broadband points set to come on stream Alan HartnettStradbally native Alan Hartnett is a graduate of Knockbeg College who has worked in the local and national media since 2008. Alan has a BA in Economics, Politics and Law and an MA in Journalism from DCU. His happiest moment was when Jody Dillon scored THAT goal in the Laois senior football final in 2016.
Health Ministry Stresses Importance of Breastfeeding UncategorizedSeptember 16, 2007 RelatedHealth Ministry Stresses Importance of Breastfeeding RelatedHealth Ministry Stresses Importance of Breastfeeding RelatedHealth Ministry Stresses Importance of Breastfeeding FacebookTwitterWhatsAppEmail National Breastfeeding Week is being observed from September 16 to 22 under the theme, “Breastfeeding: The 1st Hour – Save One Million Babies”.Dr. Eva Lewis-Fuller, Director of Health Promotion and Protection in the Ministry of Health and Environment told JIS News that the theme underlines the importance of putting the baby to the breast shortly after birth. This, she further said, gives the infant the necessary nutrition, warmth and protection that is required.“What we have realized is that establishing breastfeeding early really helps mother and baby to have a successful breastfeeding relationship henceforth. The longer you wait to put the baby on the breast, the more likely it is that the baby will not accept it,” the Director informed.“The baby is born with a sucking reflex which allows it to find the breast. If you put the baby on your chest they will find the breast and start sucking automatically and instinctively. If they are not put on the breast early enough they will lose that reflex and that instinctive behavior,” she expounded.By putting the baby to the breast in the first hour also ensures successful breastfeeding for six months at least, which is what is required. “Mothers should feed their babies exclusively with the breast for at least 6 months,” the Director insisted.While acknowledging there was a problem for many mothers to breastfeed once returning to work, Dr. Lewis -Fuller urged mothers to express the breast milk and properly store it.“Breast milk contains the ideal food for the baby in those early months .the ideal nutrition which we realize will prevent the baby getting chronic diseases later on in life and the more immediate time frame,” she noted.Elaborating, Dr. Lewis-Fuller said that after breastfeeding, the newborn is protected from infection. “The baby [is temporarily] immunized because the colostrum, which is the first milk contains what is called immunoglobins or factors that confer immunity on the babies at least temporarily for a few months, so it is very important that mothers breastfeed babies and do so early” she stated.Meanwhile the week will begin with a church service at the May Pen Seventh Day Adventist Church on Fernleigh Ave in Clarendon, starting at 10:30 a.m.“We try to rotate the locations, as most of the time activities are centred in Kingston and our colleagues say to us that Kingston is not Jamaica,” the Director said. Other church services will be held across the island.An official launch of the week will take place on September 17 at the May Pen Hospital in Clarendon at 10:30 a.m. Top health officials are expected to attend. In addition, a breastfeeding exposition will be unveiled following the launch.There will be a ‘baby friendly’ seminar in the Conference Room of the Manchester Health Department at 10:00 a.m. on September 18.On September 20 there will be a National Breastfeeding quiz for mothers and fathers in the main lobby of the Ministry of Health and Environment located on King Street in Kingston. “We will seek to reinforce some of the facts about breast feeding among parents,” Dr. Lewis -Fuller noted.Throughout the week, health centres will have displays focusing on breastfeeding and educational materials will also be distributed.Breastfeeding Week is celebrated internationally. While most countries usually observe it in the first week of August, Jamaica has opted to celebrate it in the third week of September so as to prevent it coinciding with Emancipation and Independence Day celebrations.Breastfeeding Week has been celebrated for more than a decade and is a collaborative effort with the World Alliance for Breastfeeding Action. Advertisements